In my experience, renal disease develops more often in people who have history disease such as diabetes, hypertension, heart diseases, infections.
Diabetes and hypertension will cause large amount of glycosylated substance and lipid toxic things deposited in the kidneys. It will cause inflammation in the kidneys and gradually damage the kidney function.
As for diabetic nephropathy patients, microalbuminuria is the performance of the early stage. Albumin is a kind of protein in blood, normally, there are just a few of them in urine. Microalbumin reflect your kidney is abnormal and leak protein into urine. When you find it, do pay attention, Microalbumin in urine is the early symptoms of Diabetic Nephropathy. But normally patients will not pay attention to it. So I suggested you check your microalbumin and fundus microscopy if you have diabetes.
Now let me tell you more about how the kidneys be damaged with diabetes.
In right condition, the blood vessels in kidneys help filter wastes from blood. However, in Diabetes, if blood sugar level is not controlled well, high blood sugar can destroy these blood vessels. Over time, the kidneys will lose the ability to filter blood gradually. Later it may stop working completely and develop into Renal Failure.
As to diabetes it mainly damage blood capillaries within kidneys. Diabetes will cause large amount of glycosylated substance and lipid toxic things deposited in the kidneys. It will cause inflammation in the kidneys and gradually damage the kidney function.
For DN there are 5 stages: Stage 1. gfr increase into 150-200, stage 2. gfr increase into 130, stage 3. gfr become normal 100-120 but there will be microalbumin 300mg, stage 4.gfr may decrease, and clinic albuminuria, Stage 5. gfr below 20 Cr become 400. so I suggest you test your protein in urine for 24 hours. Then you could know your condition more clearly.
Therefore, to treat diabetic nephropathy, we have to stop the inflammation, remove the toxic things and repair the damaged kidney cells. And help improve the kidney function. So that the disease can be treated well.
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